Advice You - Business

Rising production costs and fierce competition is resulting in manufacturing companies looking at all aspects of savings, especially energy savings.

Spray nozzles of the right specifica

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

tion can lead to significant savings in both energy and raw materials.

One of the overlooked areas is the use of the correct spray nozzle. Whilst frequently ignored in the manufacturing

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

process, it is often this item of equipment that is the most important. Header tanks, pumps sophisticated controls, pipe work are all immaterial if the spray nozzle “at the sharp end” is

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

not delivering the right amount of fluid (flow rate) at the correct spray angle and with the right spray pattern. This can lead to excessive wear on the pumps and ancillary equipment re

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ulting in higher energy consumption and related costs.

The phrase – it sprays, is often used, but how effectively is often not considered.

In addition to these more obvious savings the

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

e are a many “hidden” savings to be made. Expensive down time and failed equipment could be contributed to poor nozzle performance. Production lines designed to operate continuously ar

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

e expensive items if shut down owing to badly performing spray nozzles and this failure could affect the total production plant with the resulting unsuccessful distribution to customers,

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

which in turn may affect their production.

All this from the wrong or poor performing spray nozzle!!

The correct spray configuration is essential to maximise the spraying operation and

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

continuous spray nozzle development will lead to greater beneficial savings.

In addition, the wrong or worn out spray nozzle will eventually lead to poor finished products and possible

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

rejection of expensive products. This could result in extra production to make good these shortfalls, with the resulting increase in energy costs. All this will reduce profit margins.

I

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

itial investment will be required to introduce the correct nozzle, but payback can probably be counted in months and in some case weeks.

As an ongoing maintenance program, substantial s

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

avings will be made by regular inspection and maintenance of the spray operation and possible replacement when nozzles become worn, through blockages, corrosion, wear and accidental dama

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

e Regular maintenance of the spray nozzles must be undertaken to ensure the nozzles have optimum spray performance. All nozzle configurations should be analysed on a regular basis to e

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

nsure that the spray pattern, flow and operating pressure cannot be improved upon, possibly with new nozzle technology, or the fact that the application process has not changed. The latt

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

r being the case then a new specification should be sought.

As well as energy savings, raw material savings must also be taken into consideration and it is feasible to experience water

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

eduction of up to 40% in certain industries and spray nozzle applications. Also to be taken into consideration must be the application where the spray fluid is not water, but more expen

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

sive chemicals or fluids. With correct nozzle design even greater savings may be achieved. Energy savings can be made in pump operation and it some case it is possible to reduce the num

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

er of pressure pumps, thereby saving considerable operating costs and associated maintenance cost.

To summarise, energy savings, raw material savings and a reduction in the wear and tea

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

r of other equipment can all be experienced if the correct spray nozzle is specified.

The specification must include nozzle material, spray angle, spray pattern, flow and pressure. With

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

all these set correctly a regular maintenance programme should be undertaken. With the correct specification and maintenance schedule then energy and raw material savings can be expected

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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