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A metal detector is an electronic device employed to detect traces of metal, generally from the ground, a person, or cargo. Metal detectors

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

can effectively penetrate through soil, wood and other non-metallic materials.

How does it work?

Metal detectors use the principal of elec

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

tromagnetism. Typically, a metal detector comprises an electronic box, transmitter, a receiver antenna and a battery case. By battery power,

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

the transmitter generates a magnetic field. If a metal item passes through the metal detector, it becomes magnetized due to the effect of th

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

e magnetic field. On receiving the electromagnetic signature, the receiver sends a signal to the electronic box. There is a speaker to ampli

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

y this signal. This produces a beep sound, indicating that there is metal contamination.

What are the different types of metal detectors?

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

Depending on specific situations, different types of metal detectors are available. For example, there are metal detectors exclusively for p

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

rospecting gold. Likewise, special metal detectors are available for relic hunting. Underwater metal detectors, coin detectors, and walk thr

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ugh metal detectors are other prominent types. Multi-purpose metal detectors are also popular nowadays.

What is product effect?

When passi

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ng through the metal detector, some food stuffs tend to generate a signal although no metal is present in them. This is known as product eff

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ct. It is mainly due to factors including acidity, fat content, moisture content, salinity and temperature.

What are the factors that affec

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

t the sensitivity of metal detectors?

Product effect, size and type of metal contaminants, and metal detector opening size are some of the

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

factors that affect metal detector sensitivity.

What is the warm up time for metal detectors after the power is on?

For accurate detection

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

of metals, metal detectors must be allowed to warm up for at least 30 minutes after the power is on.

Can burned and rustic metals be detect

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ed using metal detectors?

Yes. But, the detection sensitivity is based on the shape and orientation of the contaminants. In addition, it is

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

difficult to detect minute particles.

Can metal detectors detect non-metallic contaminants?

Metal detectors cannot detect non-metallic con

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

taminants.

What are the accessories required in metal detecting?

Among the accessories required for metal detecting are gloves, probe, kni

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

fe, gator digger, and ground cloth.

What are the precautions to be taken when cleaning metal detectors?

To clean the main unit of metal de

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ectors, hot water less than 40 degrees centigrade can be used. The dirt and particles present in the detector head must be cleaned frequentl

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

y. It is also necessary to clean its conveyor belts. Neutral detergent and a plastic brush with soft bristles can be applied for the purpose

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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