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Everywhere we go we see or hear the word 'free' attached to every label of every prod

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

uct or service. Yet, time has taught us that everything comes at a price and our minds are sub

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

consciously programmed to steer-clear of the sinister that is called 'free'.

Your email accou

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

nt is free online, your cell phone is free with your phone line subscription, your soft drink

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

refills are free at any fast food restaurant, and even your wireless Internet access is free i

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

n most public places. But how much does 'free' really cost you?

Considering that at

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

least half of us wouldn't even bother purchasing many of these products if it weren't for the

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

free added bonuses we receive, there would be a whole lot spent on 'free'. You may buy a $3 me

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

al to get free refills with your soft drink, but there's only so much one person can drink at

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

a time. So you end up returning to that place of business -- time and time again -- assuming y

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ou're the winner. In time, however, they'll make more than enough money off of the meals you p

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ay for to compensate for the free refills they offer.

You're likely to spend $100 on your cel

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

l phone bill each month in order to get 100's of 'free' minutes that you probably don

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

't even need, when you could have spent half that and still satisfied your needs. Sitting at y

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

our local Starbucks with the added privilege of wireless Internet access is great and it won't

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

cost you anything. But it is when you order $35 of caramel lattes, as you surf the pages of c

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

yberspace, that Starbucks has successfully achieved its long-term marketing objective.

The la

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ck of consumer awareness on the dangers of 'free' marketing strategies is incredibly

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

common. It's easy to get sucked into the whorl pool of free offers, because, well, they're eve

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

rywhere. It is important to understand that free can sometimes cost a lot more than it's worth

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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