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Advice You - Predicting the Future of Business
Predicting the future of business can be a challenging task, from novices to experts, CEO’s, Investment bankers, analysts, professors and investors all have tried it in the past. While some have been successful in doing it, many have fallen flat on their faces. I hav
According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
e compiled a few colossal failures and some that were just mere hiccups, for the experts and the companies they represent.
1.“The concept is interesting and well- formed, but in order to earn better than a “C”, the idea must be feasible.” A Yale university managemen
1.“The concept is interesting and well- formed, but in order to earn better than a “C”, the idea must be feasible.” A Yale university managemen
; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.
Examples of combination products may in
Examples of combination products may in
t professor in response to Fred smith’s paper proposing overnight delivery service. (Smith founded FedEx corp.)
2.“There is no reason anyone would want a computer in their home”. Ken Olson, president and founder of Digital Equipment Corp., 1977
3."I think there is
2.“There is no reason anyone would want a computer in their home”. Ken Olson, president and founder of Digital Equipment Corp., 1977
3."I think there is
lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.
world market for maybe five computers." -- Thomas Watson, chairman of IBM, 1943
4.“We went to Hewlett-Packard and they said we don’t need you, you haven’t even graduated from college yet” Apple founder Steve Jobs on trying to get Hewlett interested in his and Steve
4.“We went to Hewlett-Packard and they said we don’t need you, you haven’t even graduated from college yet” Apple founder Steve Jobs on trying to get Hewlett interested in his and Steve
here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
Wozniak’s personal computer.
5."Stocks have reached what looks like a permanently high plateau." -- Irving Fisher, Professor of Economics, Yale University, 1929.
6.“These Google guys, they want to be billionaires and rock stars and go to conferences and all that.
5."Stocks have reached what looks like a permanently high plateau." -- Irving Fisher, Professor of Economics, Yale University, 1929.
6.“These Google guys, they want to be billionaires and rock stars and go to conferences and all that.
d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.
Combination pro
Combination pro
I don’t think they will be around running the company in two to three years”. Bill Gates in 2003
7.In February 2005, Microsoft unveils a new version of MSN search, developed at a cost of $100 million, in an attempt to take market share from Google. MSN's share of In
7.In February 2005, Microsoft unveils a new version of MSN search, developed at a cost of $100 million, in an attempt to take market share from Google. MSN's share of In
ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
ernet search traffic promptly drops by a full percentage point.
8.In 2005, H&R Block announces a review of its recent financial statements, estimating it will find discrepancies in its favor of about $19 million. Two months later it reveals that the review found $77
8.In 2005, H&R Block announces a review of its recent financial statements, estimating it will find discrepancies in its favor of about $19 million. Two months later it reveals that the review found $77
easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
million in errors--in the other direction. The company explains that it had "insufficient resources" to identify and report complex transactions in its corporate tax accounting.
9.After complaints from animal-rights activists, Kraft Foods deletes an online animatio
9.After complaints from animal-rights activists, Kraft Foods deletes an online animatio
nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
n for its Trolli Road Kill Gummi Candy that features animals amusingly caught in car headlights. The fruit-flavored Trolli candy, which comes in the shapes of squished snakes, squirrels, and chickens, is later discontinued.
10."The effect of Disney and Pixar guessin
10."The effect of Disney and Pixar guessin
and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
wrong on this was actually not giant."-- Pixar CEO Steve Jobs, defending overly optimistic DVD sales forecasts. The animated-film studio sees second-quarter earnings drop 66 percent.
11.Ex-Tyco CEO Dennis Kozlowski receives 8-25 years in prison for misusing company
11.Ex-Tyco CEO Dennis Kozlowski receives 8-25 years in prison for misusing company
ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
funds. A few of the things he did with company dollar, spent 2 million on his ex-wife’s birthday party on an Italian island and a $6000 shower curtain.
12.“Everyday for six years we’ve been shucking and jiving for the amusement of a bunch of retards and you say we’
12.“Everyday for six years we’ve been shucking and jiving for the amusement of a bunch of retards and you say we’
ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.
Following aspects would a
Following aspects would a
re not suffering enough?” Suck .com last post on its website after receiving millions of dollars in funding from investors and Venture funds and then going belly up.
13.In a press release, Gradient writes that this case "is about the rights of investors to obtain in
13.In a press release, Gradient writes that this case "is about the rights of investors to obtain in
dd to the challenges in developing combination products:
Which markets to tap where the combination products can do fairly well?
Which combination prod
Which markets to tap where the combination products can do fairly well?
Which combination prod
ormation enabling them to make better investment decisions. Gradient will not be intimidated by those who don't like our opinions and who want to strangle any and all negative comments with contentious litigation..." this is after overstock.com sues Gradient an indep
cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
endent research firm that it conspired to drive down its stock. Over the course of 2005, Overstock.com CEO Patrick Byrne issued pronouncements about short-sellers who were driving the company's stock into the ground. After listening to an Overstock conference call wi
tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
th investors in August, Dallas Mavericks owner Mark Cuban posted to his blog a list of the topics Byrne covered: "Miscreants; an unnamed Sith Lord he hoped the feds would bury under a prison; gay bath houses; whether he was gay, does cocaine, both, or neither; phone
t?
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
aps; phone lines misdirected to Mexico; arrested reporters; payoffs; conspiracies; crooks; egomaniacs; fools; paranoia; which newspapers are shills and for who; money laundering; his Irish temper; false identities; threats; intimidation; and private investigators. Al
ping new procedures for reviewing their safety, efficacy and quality.
Professional from academic institutions, pharmaceutical industries, health care indust
Professional from academic institutions, pharmaceutical industries, health care indust
l in 61 minutes." Cuban then short-sells 10,000 shares of Overstock.
14.Polaroid is sold to the Peters group after 3 years in bankruptcy. Chairman Jacques Nasser walks away with $12.8 million, CEO J. Michael Pocock gets $ 8.5 million meanwhile retirees lose their me
14.Polaroid is sold to the Peters group after 3 years in bankruptcy. Chairman Jacques Nasser walks away with $12.8 million, CEO J. Michael Pocock gets $ 8.5 million meanwhile retirees lose their me
y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
dical and life insurance benefits and only receive one time checks of $ 47.
While these are but a few of the really funny mistakes made by our predictors, you imagine if you were an investor or worked in the companies at the time when these events occurred, the resu
While these are but a few of the really funny mistakes made by our predictors, you imagine if you were an investor or worked in the companies at the time when these events occurred, the resu
.
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
ts would have been really disastrous for you because we all know that those who suffer when company’s management make the wrong assumptions about their future and the industries they compete in is the Investors, employees and retirees, so after you have had your laug
elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.
Companies that provide selfless information through particip
Companies that provide selfless information through particip
h maybe next time someone decides to gamble with your future you will be well prepared with all the information and tools necessary to make sure you are in control of what happens, it is by the way your future isn’t it.
Ronn Machio
ronnmachio@earlywarningmanual.co
Ronn Machio
ronnmachio@earlywarningmanual.co
tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products
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