Advice You - Business

Injection molding is a manufacturing technique for making parts from plastic material. Molten plastic is injected at high pressure into a mould, which is the inverse

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

of the desired shape. The mould is made by a mold maker from metal, usually either steel or aluminium, and precision-machined to form the features of the desired part

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

Injection molding is very widely used for manufacturing a variety of parts, from the smallest component to entire body panels of cars. Services offered by providers

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

of liquid injection molding include bonding, design assistance, graphics, tool or mold making, prototype or market entry molding, low volume production, high volume p

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

oduction, micro molding, large part molding, insert molding, two-shot injection molding, stamping services, assembly services, just-in-time capability, and packaging

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

and shipping.

Liquid Injection Molding
Nowadays, liquid injection molding is becoming increasingly important. One reason for this is the increased performance r

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

quirements of the finished rubber parts. In addition, more and more producers of rubber parts are seeing the benefits in the high level of automation and productivity

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

. Injection molding technology, using liquid rubber, combines the speed, cost efficiency, and versatility of plastic injection molding with the outstanding properties

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

of silicone rubber. It is used in many applications where organic rubber cannot perform, such as military, aerospace, automotive, healthcare applications, etc. The us

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

e of silicone rubber combines the properties of resilience, high temperature stability and inertness as silicone is generally unaffected by temperatures from 100 degr

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

es Fahrenheit to 450 degrees Fahrenheit. Progress in liquid injection molding technology has made faster cures possible, enabling unit cost reductions.

Some common m

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

olding problems and their remedies

Scorch
Scorch is premature vulcanization of the rubber, before the flow of rubber in the mould is completed. The poor mould f

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ow results in distorted or incompletely formed parts. To prevent or eliminate scorch, see that the mould is completely filled before the rubber starts to vulcanize. A

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ssure that the mould cavity is uniformly heated.

Backrinding
This is distortion of the molded product at the mould parting line usually in the form of a torn or

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

a ragged indentation. Backrinding is generally caused due to sudden release of internal pressure within the part when the mould is opened. So to prevent it make sure

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

there is no roughness or excessive opening at the mould parting line and keep the molding temperature as low as possible for the vulcanizing agent used.

Entrapped ai

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

Air entrapped in the mould or the rubber may produce soft, discolored areas in the surface or in the cross section of the molded part due to incomplete vulcaniz

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ation. Remedies include
- Bump the mould
- Increase the amount of vulcanizing agent.
- Use a high temperature-vulcanizing agent that is less reactive

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ith air.
- Vent the mould at sharp corners and undercuts.

Surface discoloration
This usually results from excess build up of mould release agent in the mou

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ld cavity, or from excessive dust or dirt in the preform. To prevent it clean the mold as often as necessary and keep the preforms clean. Use release agents sparingly

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

HTTP = HTML link (for blogs, profiles,phorums):
<a href="http://www.adviceyou.org.ua/article/3944/adviceyou-Injection-Molding.html">Injection Molding</a>

BB link (for phorums):
[url=http://www.adviceyou.org.ua/article/3944/adviceyou-Injection-Molding.html]Injection Molding[/url]

Moving Boxes and Supplies play a vital role in moving. Packing paper, Packing tape, Marker or good pen, these are few things which play important role while you plan to move. Redline Moving is the professional moving company making your move easy and convenient.

Are you sick and tired of getting harassing telemarketing sales calls while you are trying to get your work done. Stop these harassing calls easily with just a few steps.

Professional Sports recruitment practices can help managers place a greater focus on strategy in their selection efforts. This approach can also help the manager think more logically about the potential of his/her team and creative ways to boost team performance and succession potential.

Tags

Links

Advice You - Injection Molding

Related Articles: