Advice You - Internet and Businesses Online

Whenever your click on a link or type an address into your web browser you're making a "request" for that particular page. That request is hand

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

led by what is known as the Hyper Text Transfer Protocol (HTTP). The request gets routed over the internet to the appropriate server and if eve

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

rything goes according to plan, that server will send the page requested back to your browser.

HTTP is an integral part of the Internet Protoc

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ol (IP) suite. It's used by browser software to connect to the server that holds the website you want to see. The server watched for these requ

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ests by monitoring what is called a TCP port (port 80 in most cases).

Transmission Control Protocl (TCP) is the protocol that creates connecti

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ons between two computer over the internet, allowing them to pass data back and forth. TCP is made to allow the transmitted data to be reassemb

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

led into the proper form when it reached its destination.

There are a number of TCP ports that monitor specific protocols. For example, TCP po

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

rt 21 is normally used for FTP (File Transfer Protocol) and port 80 is normally used for HTTP (web browsing).

If a web server gets a request o

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

n port 80 in the form of GET / HTTP/1.1 it sends a response code that tells the requesting computer whether the page is available or not. A typ

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ical request will look like this:

GET /faq.html HTTP/1.1
Host: http://www.mywebsite.com

This request is for a web page at http://www.myw

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ebsite.com/faq.html. The "host" is specified to identify a particular website on that server (in the case of shared hosting, there can be many

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

sites on one server).

If the faq.html page is available, the response will be:

HTTP/1.1 200 OK
Date: Mon, 15 November 2005 13:22:54 GMT

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

Server: Apache/1.3.27 (Unix) (Red-Hat/Linux)
Last-Modified: Wed, 23 Aug 2005 08:23:33 GMT

...after which the contents of the actual

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

web page will follow.

Let's break that response down...

HTTP/1.1 200 OK means that particular web page is available. Other codes may be retu

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

rned. For example, the code 404 means the requested page cannot be found. You've probably seen 404 errors when you've clicked a link to a non-e

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

xistent page or misspelled a web site when you entered in in your browser.

The date is self explanatory and the server is information about th

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

e software running on the server that is hosting the web page.

When the web page is being sent to your browser, it gets sent in "packets" of i

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

nformation. The header also contains information that specifies its order in the stream. These packets can be sent through various routes to ge

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

t to your computer, so they all get reassembled by your browser when they arrive.

This normally all takes place in seconds, so you see the web

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

page as it was meant to be seen even though all the various packets may have taken completely different paths from the server to your computer

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

HTTP = HTML link (for blogs, profiles,phorums):
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BB link (for phorums):
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John Dewey, a 21st century renowned philosopher, psychologist and educator said that the need to feel important is a basic law of human nature. When you are contacting your sales prospect, engaging in conversation with them and even speaking with their gatekeeper it is so important that you apply this law of human nature. This articles discusses ten practical ideas that you can use to make others feel important. And as a result of your efforts, you will find yourself closing more sales!

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