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HTML is not a friendly language for laying out text and graphics. The advent of Cascading Style Sheets improved this, but a simpl

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

e solution to the problem of layout is to use tables without borders. Within HTML, this can be done by adding the attribute BORDE

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

="0" to the TABLE tag. However, most HTML editors, such as Dreamweaver and FrontPage, allow you to set the border to 0 as one of

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

he properties of the table.

Perhaps the biggest problem newcomers face is in finding appropriate images that look good. In many

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

cases, images are found using a simple Google image search. More often that not, these images will be under copyright and using t

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

em risks potential legal action. One way around this is to purchase royalty-free images on CD / DVD or directly from the Web. Of

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ourse, you need to be careful to check the license agreement. For example, the images may only be royalty-free for non-commercial

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

uses. Another solution is to take your own images using a digital camera (or scanning in your own photos). Again, to minimize th

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

risk of legal action you should obtain permission from people shown in the photos before placing them on the web.

Even after lo

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ating or creating images, a good design may still be difficult given the 'blocky' nature of the photos that are typically in a re

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

tangular shape. This leads to the major tip for improving your web site design. If using stock photos, look for 'photo-objects' r

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ather than photos. These are photos which have had the background removed. Where the background should be is actually transparent

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

which means you can put the photo-objects on any background.

When using your own images, you can easily create photo-objects by

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

using a 'green screen' behind the subject you are photographing. You can load the image into any piece of imaging software that h

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

as a magic wand tool. Then simply click on a section of the green screen and press delete to remove the background.

There is not

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ing 'magical' about a green screen. Any piece of material that has a consistent color and is fairly flat will do. Green or blue w

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

rk best because these are very different from skin tones that won't disappear when you use the magic wand. (Of course, if they ar

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

e wearing green clothes these may suddenly become transparent).

Backgrounds can be removed using a magic wand tool (and eraser f

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

r fine details) from photos with a normal background, but expect to take many steps and more time. Even if you can't remove the b

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ckground you can add some spice to your images with simple steps such as adding a drop shadow or adding a frame like a photograph

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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Fleeced, ripped-off, cheated, conned. We're all afraid of losing money to wholesalers who turn out not to be the real deal. The horror stories can certainly be very off putting – especially to those just getting started. The trick is to spot it and stop it before it's too late!

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