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    In my role I get to meet literally hundreds of online content publishers every year and the question I'm most frequently asked is:

    “Shoul
    According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
    d we give our content away for free and make our money from advertising, or should we charge people to get access to our content?"

    Our an
    ; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

    Examples of combination products may in
    wer is always the same.

    “If you can make as much money giving your content away for free and selling advertising space against it, as you
    lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

    can make from running a paid subscription website, then go the free content route. It is simpler”.

    However for 90% of specia
    here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
    ist information publishers they will never make as much from advertising revenues as they can from subscriptions and these are the reasons
    d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

    Combination pro
    why.

    Reason #1 – We Only Hear About the Headline Advertising Figures

    Anyone vaguely involved with the int
    ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
    rnet will frequently see figures being quoted about the size of the online advertising market and how quickly it is growing. But rarely do
    easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
    we see a breakdown of how these revenues are distributed. So here it is:

    72% of all online advertising revenues go to just 10 companies
    nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
    br> 95% of all online advertising revenues go to just 50 companies

    That leaves just 5% of the remaining revenues being distributed among
    and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
    st tens of thousands of websites which are trying to make money from advertising. And amongst this group who have to pick up the scraps of
    ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
    the rich advertisers table are many big international publishers. They are taking a big chunk of the remaining 5%!

    To put some numbers a
    ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

    Following aspects would a
    ound these facts:

    In the US 5% of advertising revenues in 2005 was $620m
    In the UK 5% of advertising revenues in 2005 was ?40m

    The
    dd to the challenges in developing combination products:

    Which markets to tap where the combination products can do fairly well?
    Which combination prod
    se are not big figures when you take into account how many thousands of websites are trying to get a piece of the action.

    Reason
    cts are meaningful and rational?
    Which therapeutic categories to select?
    Which Combinations can address unmet needs of the patients?
    Do combin
    2 – Advertising is Driven by Traffic Volumes

    The second reason is, like it or not, online advertising revenues are still largely
    tions increase the patient compliance?
    What would be the developing cost?
    How to tackle the risks encountered during combination product developmen
    driven by volumes of visitors to a website. The typical rates are $8/?5 per thousand pageviews (even for Adsense). To make $100,000 or ?6
    t?

    As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
    ,000 in revenue you would need to be getting over 34,000 pageviews a day on your website.

    Successful specialist online publications typic
    ping new procedures for reviewing their safety, efficacy and quality.

    Professional from academic institutions, pharmaceutical industries, health care indust
    ally rely on having a low volume of highly interested and loyal readers. This does not suit a volume driven advertising model.

    Co
    y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
    clusion

    There are only two ways of making money from content on the web. Free with advertising, or paid for access. Advertising
    .

    As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
    is volume driven so does not suit niche sites with low numbers of loyal followers. Therefore content owners have one alternative and that
    elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

    Companies that provide selfless information through particip
    s to charge for the content. They can do this as one off downloads or provide access to content on an ongoing basis for a subscription fee


    tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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