Advice You - Internet and Businesses Online

Since the introduction of the internet, many people have realized the advantage of using it as a tool for research and information gathering. And through the years,

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

Google has become one of the most prominent search engines due to its simplicity of usage. Internet users find it very convenient to use Google’s search capability

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

to find new information about various topics.

Google uses a very sophisticated system that employs the use of algorithm, the PageRank algorithm. This is a search m

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ethod that enables the web portal to effectively search for web pages based on a particular search request.

The early development of web pages used a system that i

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

generally different from the concept of page ranking. Even today, this type of system is employed by some search engines. Search phrases are identified based on th

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

occurrence on a particular web page. This occurrence or hit is then weighted based on the document’s length, its presence in the underlying HTML tag or even by key

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

word density.

In further development, search engines devised a system which eventually makes searches more resistant to electronically and instantly generated web

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ages. This was based primarily on the search criteria with a more generic form of search documents. However, as this type of system did not promise to be a better a

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

pproach in searching files, the link popularity was developed. Link popularity identifies the number of linked documents as the measure of its importance. Hence, a

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

articular web page is deemed important for a search if more links are imbedded in it compared to other web pages.

This system may be more efficient than phrase sea

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ching but it does not eliminate the possibility of having dummy searches. Apparently, there are millions of websites that can be linked to each other based on a cer

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

tain key path. Even though the web page is not significant for the search, it may still be prioritized based on the number of links.

How do Google Pagerank algorit

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ms work and differ from other search methods?

Generally, when you do a search using Google, the portal searches for a document that is more important not based on

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

inbound links. These documents are prioritized if other high ranking documents are linked to it. Thus the accumulation of higher order ranking is maintained within

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

he search. High ranking documents are then filtered out to acquire a much higher ranking document until your search is completed.

Lawrence Page and Sergey Brin are

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

the first to introduce the PageRank Algorithm in this formula: PR(A) = (1-d) + d (PR(T1)/C(T1) + ... + PR(Tn)/C(Tn)).

A page rank system does not rank websites in

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

general item but is clustered for each page individually. Subsequent pages under a ranked page support the overall ranking of the whole document.

For example, if w

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

are to use a model with three pages A, B, C; with this relationship, A is linked to B and C, B is linked to C and C is linked to A.

Since A is linked to both B an

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

d C, it (A) can be supported by both pages. If in any case B and C are highly ranked by previous searches, A will definitely benefit from it to succeed as a higher

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

anking page. Whereas, for both pages B and C, since they are linked to A independently, they may also be hit by a search but on the lower case of rank compared to A

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

HTTP = HTML link (for blogs, profiles,phorums):
<a href="http://www.adviceyou.org.ua/article/74858/adviceyou-Google-Page-Rank-Algorithm.html">Google Page Rank Algorithm</a>

BB link (for phorums):
[url=http://www.adviceyou.org.ua/article/74858/adviceyou-Google-Page-Rank-Algorithm.html]Google Page Rank Algorithm[/url]

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