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Some internet search engines are set up to look for keywords throughout a webpage, they then use a mathematical equation that takes in the amount of time t

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

he keywords appears on the webpage and factors it with the location of the keywords to determine the ranking of the webpage.

Other internet search engines

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

use a process that judges the amount of times a webpage is linked to other web pages to determine how a webpage is ranked. The process of using links to d

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

etermine search engine ranking is called link analysis.

Keyword searches and link analysis are both part of a routine internet search engine procedure cal

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ed search engine optimization. Search engine optimization is the art and science of making a website attractive to search engines, the more attractive a we

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

bsite appears to the search engine the higher it will rank in searches and in the world of internet searches ranking is everything.

As 2006 faced its last

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

weeks, Google was the internet search engine that most internet users preferred. Approximately fifty percent of the times a consumer turned to a search en

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ine for their internet needs they turned to Google. Yahoo! was the second favorite.

Most of Google's popularity is credited to its preferred form of searc

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

h engine optimization, a trademarked program Google dubbed PageRank. When PageRank was patented the patent was assigned to Stanford University.

PageRank w

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

as designed by Larry Page, (the name is a play on his name) and Sergey Brin while they were students at Stanford University as part of a research project t

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ey were working on about internet search engines.

PageRank is based on the link analyses algorithm. PageRank is described as a link analysis algorithm tha

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

t assigns a numerical weight to each individual element of a hyperlink set of documents. The purpose is to measure its relative important with the set. The

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

numerical weight assigned to any element is called PageRank of E. PR(E) is the denotation used.

PageRank operates on a system similar to a voting booth.

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

Each time it finds a hyperlink to a webpage, PageRank counts that hyperlink as a vote that supports the webpage. The more pages that link to the page, the

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

more votes of support the webpage receives. If PageRank comes across a website that has absolutely no links connecting it to another webpage then it is not

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

awarded any votes at all.

Tests done with a model like PageRank have shown that the system is not infallible.

The HITS algorithm is an alternate to the

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

PageRank algorithm.

Google's powers that be take a dim view on spamdexing. In 2005 Google designed and activated a program called nofollow, a program they

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

designed to allow webmasters and bloggers to create links that PageRank would ingnore. The same system was also used to keep spamdexing to a minumum.

Goog

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

le has designed PageRank to be an eight-unit measurement. Google displays the value PageRank places on each website directly beside each website it display

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

s.

It has been proposed that a version of PageRank should be used to replace ISI impact factor so that the quality of a journal citation can be determined

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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