Advice You - Internet and Businesses Online

Natural linking to add related one-way links to your website is an accepted method for boosting search engine ranking. Done properly, the results will be worthwhile. If you are determined to take shortcuts, conside

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

r the consequences. There are valid services who will hand submit your URL to directories, and the best will provide evidence of value for money paid.

Quick and low cost solutions may backfire because others may br

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

oadcast your site to 500-1000 or more sites for $19.95, or some similar number up to $99, with varying results. You may see ads for one million sites for some ridiculously low amount. You need to think twice about

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

where your www domain will end up listed. A low price may not be a good price.

None of the services can guarantee you will be approved and listed to all that receive your submission. Each directory has rules, and

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

although some will automatically add your URL, most are reviewed by a human editor prior to approval.

My advice is doing it yourself. Unless you hand submit your www domain to website directories, the quality backl

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

inks you expect from a service company could leave you wondering if your efforts were in vain. By physically visiting each site and reviewing their guidelines, you improve your chances of being approved. More impor

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

tantly, the rules change.

For example, I developed a list of 150 well established directories that accept free listing of your URL. For natural listing, I choose to submit 5 per day to avoid a spike in backlinks th

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

at may be perceived as spam by the search engines.

In the course of submitting over several months, I discovered some directories change policy due to the large number of sites submitted and then they do one of thre

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

e things. They charge a fee, require a reciprocal link, or temporarily discontinue accepting free submissions. Broadcast submissions will fail without picking up this valuable information, so many will not be appro

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ved.

The first step is making sure your website is ready to submit. Be prepared with quality content and then do search engine optimization review prior to submitting to website directories. Use these guidelines t

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

o determine if your site is worthy. Keep in mind these are general rules, and may vary from one directory to another. Each listing structure may be organized with variable categories, so an automated system may not

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

properly evaluate the rules.

Do not submit:

1. websites under construction
2. more pages other than your home page
3. to unrelated categories
4. porn, vulgar, hate, or illegal content sites
5.

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

sites in languages other than English
6. pages with plug-ins, pop-ups, or flash only design
7. any graphic only sites with unreasonable load time
8. just your sitemap, a pdf, or catalog only page

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

9. a site designed primarily with ads or affiliate links
10. a mirror site with duplicate content to another URL
11. the same URL disguised to try to get multiple listings
12. to unique niche directori

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

es if your site is unrelated

Some website directories will tolerate minor violations of the above rules. For example, some may allow you to submit multiple pages of your www domain. Most will not list subdomains f

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

rom free hosting services. If you have built high quality unique content on a free hosting service, some directories may make an exception. By physically visiting each directory, you have the opportunity to evaluat

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

e each based on first impression, other sites listed, and any special rules that may affect your approval.

Bonus Tip: Do not use a free service email address when submitting to directories. Most require that you p

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

rovide a working email address to qualify for submitting your URL. Some may not tell you, however, most expect that the email address provided includes the same ending as your www domain. The editors are often too

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

busy to respond to each site submitted, so if you are not approved, they won't tell you.

Finally, if all this seems like a lot of work, it is. The preparation and time to submit requires long hours. Fortunately, y

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ou may spread out the task over time to make the job easier. Once you're ready, do 5 a day for natural linking, and your listing in 100-150 directories should be accomplished in less than 2 hours a day over 30 days.

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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