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Before search engines got smart, a site's page ranking was based on keyword match-ups. When webmasters stock-piled their sites w

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ith keywords, the wrong sites were getting too much attention. Google decided to focus on a site's "popularity" instead. The nu

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

mber of incoming links became the focus of PR criteria. The theory behind this system was that if a lot of sites link to another

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

site, that site would contain valuable content.

But again, webmasters got sneaky. With this trend, we began to see the evolutio

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

n of "Link Farms" and "Free-for-All" (FFA) sites. These pages were essentially a gigantic collection of (often times) useless li

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

nks. In most cases, the sites were not categorized or descriptive. They became a place for webmasters to dump their links in or

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

er to make their site appear more popular.

This strategy worked for some time, but soon search engines caught on. "Link Farms"

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

and FFA sites served no purpose to web users. Since Google prides itself on catering to web users (and NOT developers), a soluti

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

on had to be formed. "Link Farms" were cluttering up the web and making it more difficult for users to find valuable resources o

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

line.

Google soon began to rate the quality of the links that determined a site's "link pop." "Link Farms" and FFA sites became

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

categorized as spam, and thus contributed no value to a site's link popularity.

Today, submitting to a "Link Farm" or FFA site

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

can be harmful to your website's reputation. Google takes a strong stance against these kinds of link pages. At best, the "Link

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

Farm" will drag down your ranking and make it harder for the valuable sites to work in your favor. At worst, your site will be B

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ANNED altogether for using spam sites to attempt to generate traffic. This is a very real possibility.

"Link Farms" and FFA sit

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

es present very little value. Although it may sound tempting, users will not obtain quality or relevant links from the submissio

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

. Plus, who wants to see their link among "junk" websites for adult entertainment, dating sites, and casinos? Submitting to "Li

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

nk Farms" doesn't contribute to your credibility and is just not worth the risk.

Instead, spend your time submitting to credible

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

directories and exchanging links with other relevant sites. The process can be time-consuming, but it is the only way to genera

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

e safe, site-specific traffic.

For an easier method to the tedious directory submission process, and to Submit your website to 3

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

00+ link directories fast and easy we recommend Directory Submitter

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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