Advice You - Business

Whenever you are asked to prepare an annual report or a technical paper, you want it to look as professional as it can be. The same thing is true with client presentations. And aside from making your document look professional, you wo

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

uld also want to protect it with covers so that I can be used for a longer time. There are many applications that can enhance the appearance of documents while protecting it better. Among them are binding machines. Binding machines, o

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

binders, are machines used to align, punch, and enclose individual sheets of papers into document sets. With binding machines, you can make documents look more professional, keep them well protected and lengthen their usage life.

1.

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

Document Protection

Now, all binding can enhance the appearance of documents and protect them from damages. Choosing a binding machine to use for your report or paper, however, is not as simple as just picking any binder you can find

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

in the market. There are many types of binding machines and each type would differ in price, binding method, capacity and a lot of other things. The question now is what kind of binding machine would you want to purchase?

2. What Kin

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

Of Document To Bind?

Different kinds of documents require different styles and not all kinds of binding machines can give your document the binding style it needs. Decide whether your document needs a traditional finish, a book-styl

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

finish, a contemporary finish or a finish with some metallic appearance. Then, base your choice on this decision.

3. How Thick?

Each type of binding machine has a limit on the thickness of the document it can bind. Some binding mac

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ines can bind documents of up to 3 inches in thickness while others are limited to binding I inch documents.

4. How Will The Machine Be Used?

If the binding machine would be used at home or in a home office, and not regularly at tha

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

, then a simple and affordable binding machine would generally be recommended. Larger offices that demands more binding jobs would need some complex and electrical binding machine unit.

5. Binding Machine Options

After you’ve answer

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

d all the questions and have eventually determined what kind of binding machine you need for your documents, then it is time for you to consider your options. There are a lot of binding machines available today and each of them has th

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ir own set of strengths and weaknesses.

- Coil Spiral Binding Machine

- Plastic Comb Binding Machine

- Wire Binding Machine

- Thermal Tape Binding Machine

6. Coil Spiral Binding Machines

Coil or spiral binding is probably the mo

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

st recognizable type of binding technology. It is the type of binding that one usually sees in blank notebooks. Coil binding machines are available in table top and floor standing models. These machines are also available in manual or

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

electric configurations. Spiral binding machines bind documents by (1) punching holes on the pages, (2) inserting the coil, and (3) crimping and cutting the coil ends.

- Offers a unique and contemporary finish to documents

- Can bin

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

documents of up to approximately 1 inch in thickness

- Ideal for low volumes of binding and generally used by organizations like schools and churches

7. Plastic Comb Binding Machines

Plastic comb binding machines are among the mos

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

popular binding machines today. These binders use a plastic binding with many combs inserted into holes punched along the edge of the stack of papers.

- Offers the best known, traditional finish

- Has the capacity of binding docume

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ts of up to 2 inches in thickness

- Easy to use, easy to assemble, durable, economical and reusable

- Ideal for home use as well as in most schools and businesses

8. Wire Loop Binding Machines

Wire loop binds appear like a combina

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ion of coil bound and plastic comb bound documents. This is because wire loop machines use wires in double loop design. Once inserted into the document, this wire loop will then be closed by the machine or a separate closer.

- Offers

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

a clean and stylish premium metal finish

- Bind documents of up to 1 inch in thickness

- Ideal for binding presentations, manuals and sales materials

9. Thermal/Tape Binding Machines

Unlike all of the other types of binding machin

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

s, tape or thermal binding machines don’t punch holes into the document. And neither do they use inserts to hold the stack of papers together. Instead, these machines use tape or thermal glue to bind the spine of the stack of papers.

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

- Provides a hole-free, book-style finish

- Can accommodate documents of up to 5 to 500 sheets of paper (or approximately 2.25 inches in thickness

- Ideal for high volume binding jobs or for binding hundreds of document sets per hou

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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