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Globally the Apache web server software is installed on almost two thirds of all servers, and with Apache come the incredibly powerf

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ul but very mysterious .HTACCESS file. Most people only use the file for simple password protection, but it can be used for much mo

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

e than that. This article will help to show some of the possibilities that lie within your site's .HTACCESS file

One of the neat

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

eatures of the .htaccess file (please note, the filename must always be in lowercase), is that file can be edited on with almost any

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

text based editor (such as the Windows Notepad).

Controlling if files are downloaded or Opened in the Visitors Web Browser

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ith the following code snippet, the site owner can determine how the file is download. This example (with files as .gz, .pdf, .zip

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

nd .rar) forces the file to be downloaded directly rather than having the browser attempt to open the file in the browser window.

<

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

xmp>

ForceType application/octet stream </FilesMatch>

Allow only certain

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

sers access to the server based on their IP address

The following code snippet allows only users of a certain IP address (in th

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

s case 27.101.84.200) access the the server. All other users are rejected.

order deny, allow

allow from 27.101.84.200

deny from

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ll

Deny Access to certain Files

The following code snippet, determined what files can be access. In this example, all acces

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

to files starting with "." symbol are declined. This will stop people from access (or viewing) your .htaccess file

<FilesMatc</div><div class="t2">dd to the challenges in developing combination products:<br/><br/>Which markets to tap where the combination products can do fairly well?<br> Which combination prod</div><div class="t1"> “^ .” >

deny from all

</FilesMatch>

Allow Server Side Includes on your Site

This code line will ensure

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

hat files, which contain server Side Includes (SSI), will also get processed with they carry the .html file extension

Addhandler se

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

rver parsed .html

Error Handling

When an error occurs on your website, such as a person tries to access a file that does no

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

exist, then the .htaccess file can display a "customized" error page for that particular error:

For example:

Error document 404 /

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

04error.html

Now when a user tries to access a file that causes a 404 error to be generated, the .htaccess file will now load an di

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

play the html file called 404error.html Please Note: This file must live in the root directory of your web site's structure (i.e. i

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

a LINUX installation, in your /public_html/ folder).

Sometimes Microsoft Windows has a problem with filenames that have a "." symb

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

l as the first name. To overcome this simply upload the file as something different and then rename the file when its on the server

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

HTTP = HTML link (for blogs, profiles,phorums):
<a href="http://www.adviceyou.org.ua/article/86743/adviceyou-The-Mysterious-HTACCESS-file.html">The Mysterious .HTACCESS file</a>

BB link (for phorums):
[url=http://www.adviceyou.org.ua/article/86743/adviceyou-The-Mysterious-HTACCESS-file.html]The Mysterious .HTACCESS file[/url]

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