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Often when setting up PHP scripts on web hosting accounts you will see the requirement to set some files and directories to Chmod 777. This means everyone can re

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ad, write and execute this items. On the surface this looks like a security risk but with a properly configured server this is security risk is eliminated.

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

Q. Should EVERYTHING be chmod 777 then when installing PHP scripts?
A. Not really. Just the required directories, and all the files and

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

irectories inside them. Again it won't effect security if you do, so long as the server configuration has a normal security configuration.

Q. A

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

cess by "Owner," "Group," and "Everyone." are what the numbers mean, so can anyone change files set to 777 because they are writable to everyone?
A.

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

Um, on the surface, yes. But, looking deeper the person must first get access to your server and be able to view the file to do that. They additionally need ac

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ess to the files directory, and the directories directory that file located all the way up the point they try to access your files. Reasonably you will have a di

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ectory (like your user name) which is not chmod 777. This is normally set to chmod 111 by the host at account set up.

Q. Would it be safer not

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

to use chmod 777? Could a hacker exploit it if they got in?
>A. When a hacker gets in and starts causing trouble not much will stop them. Even with th

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

file permissions as strict as possible other opportunities would be exploited, like databases will be wide open. So, yeah... you can ensure some files that are

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

not change or deleted, but not all.

Q. Is it likely a hacker would get into my server to access the mysql database?
A. Yes as likel

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

just as much as getting in to edit files, by editing your files the hacker can change things like what is displayed on your web pages, buy normally stored in th

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

mysql database are items like e-mail addresses and passwords that can be much more valuable in terms of cash. A database is chmod 777 at all times when you thi

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

k about it.

Q. Can MySQL permissions be used to secure it form intrusion as well? if I make it so they users can not delete what will happen?

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

br>A. Most scripts will not work with limited settings like that. Scripts need to be able to delete content at times. If the script can delete, so can a

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

hacker. So the key is keeping them out of the server before this point is the only real solution.

Q. Still my host does not want me setting th

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ngs to chmod 777 because they say it is not safe?
A. Tell them to read these explanations. When they cannot prove anything here to be wrong then the

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

should allow you the 777 files and directories. In case they still refuse to see logic then maybe you should find a new web host that is more knowledgeable.

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

>
Q. So with Chmod 777 not being a security problem, why should I use other chmod settings?
A. Because we all take a maximum security vi

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

w point and keeping chmod settings lower than 777 will simply provide additional security for each individual file. This is part of a maximum security philosophy

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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To process the form or mode of a signal so as to make it intelligible to, or compatible with, a given device, including such manipulation as pulse shaping, pulse clipping, compensating, digitizing, and linearizing.

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