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Most conventional analytical techniques cannot be applied to junior explorati

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

on companies. Most juniors lack either a property with a PROVEN economic ore

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

body or sufficient capital to attain production should a mine be found. How t

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

hen are junior companies evaluated? The following are some factors to be cons

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

dered:

1) Extent of exploration activities and location of properties

2) Ma

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

nagement's track record - Is management experienced? Have they discovered or

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

do they operate any producing mines?

3) Financial position - Is there enough

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

working capital to finance exploration or will more treasury shares have to

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

e issued ?( this is where dilution comes into place )

4) Common shares issue

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

d - How many common shares are issued and outstanding? (o/s) If a company has

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

few assets and a great number of common shares o/s ( I smell OTC ... ), a re

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

verse stock split may be necessary before new equity capital can be raised.

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

uccessful analysis of junior mining companies and their correlating share pri

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ce requires SPECIALIZED knowledge (Shhh, can you keep a secret), patience and

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

willingness to devote a great deal of time to security selection. Shares of

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

junior mining companies can resist sharp price fluctuations in response to fa

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

orable or unfavorable news or rumors. Nimble trading is required if profits a

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

re to be realized or losses minimized.

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As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

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elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

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tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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