Advice You - Finance

Greenbacks. Moolah. Dough. Benjamins. All nicknames for the one thing we’re all in an endless quest to get more of—cash money. It’s as much a part of our everyday lives as is sleep, food, e

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ven breathing. But have you ever really stopped to take a look at these little green monsters that seem to run our lives?

If you really take a closer look at our notes of legal tender, the

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

re’s really quite a bit going on. So the next time you’re not busy spending one—or if you have absolutely nothing else to do—grab a dollar bill from your wallet and take a good long look at

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

it. After you read this article, you’ll finally know what all those symbols and strange words mean.

First things first, feel the money in your hands. Doesn’t really feel like paper, does

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

t? That’s because it isn’t. Paper money isn’t really paper at all. It’s actually a linen and cotton blend—a cloth! That’s why it doesn’t fall apart when it goes through the washing machine.

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

In fact, there are even tiny red and blue silk fibers running through each bill.

Now, take a good look at the overall design. The dollar bill we use today first was first put into circula

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

tion in 1957. The ink used for printing is made of a secret blend—one of many built-in security features used to prevent counterfeiting.

Take a look at the front first, to the right of the

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

portrait you’ll notice a green stamp—the seal of the U.S. Treasury. It includes scales representing a balanced budget, a carpenter’s square signifying an exact cut, and a key to the Treasur

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

y itself. On the front, you’ll also notice green serial numbers, the signatures of the U.S. treasurer and secretary of the treasury at the time the bill was printed, and the seal of the min

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

t where the bill was printed.

Now, turn the bill over. You’ll notice a circle on either side. Together, they represent the Great Seal of the United States, created by Benjamin Franklin and

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

a group of our country’s founders in 1782. Go to the left circle first and look at the pyramid. The face is lighted while the western side remains dark. The darkness signifies the Western U

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

.S., which had yet to be explored. The unfinished pyramid represents the untapped potential of the country, while the all-seeing eye hovering above is symbolic of a divine being overseeing

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

mankind. In this circle, you’ll find two Latin phrases, “ANNUIT COEPTIS” (God has favored our undertaking), and “NOVUS ORDO SECLORUM” (A new order has begun).The Roman Numerals at the base

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

of the pyramid translate to 1776.

The circle on the right might look more familiar to you. That’s because it’s prevalent on many national monuments, cemeteries, and—though slightly tailore

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

—is also the Seal of the President of the United States. The centerpiece of the Seal is the Bald Eagle. It was selected as the official symbol of the U.S. for a couple of reasons: Though no

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

t afraid to weather a storm if he must, the eagle first looks to fly above it. Also, though it may appear so, the eagle wears no actual crown—symbolic in the country’s break from the King o

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

f England. Additionally, the eagle’s shield requires no support; it now can stand by itself.

Other details of note: the white bar on the top of the shield represents the unifying power of

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ongress, the term “E PLURIBUS UNIM” means “one nation from many people”, and the 13 stars signify the 13 original colonies. The eagle holds an olive branch in one set of talons arrows in th

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

e other. His gaze, though fixed at the peace-representing olive branch, won’t hesitate to turn to the sling of arrows if need be.

So there you have it; all you ever wanted to know about th

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

e design ideas behind our beloved U.S. currency. Use it to enlighten guests at your next dinner party, or inform the guy at the coffee shop as you hand him a five dollar bill for that latte

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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